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Definitions (40)
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adjuvant
a pharmacological agent that is added to a vaccine to enhance the immune response of the vaccine recipient.
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Affinity maturation
- the process by which B cells produce antibodies with increased affinity for antigen during an immune response.
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antibody
a protein molecule that is made and secreted by B cells in response to stimulation from antigens, such as viruses. Each antibody specifically binds to one antigen, which they target for neutralization [..]
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antigen
a foreign substance, such as a virus, that enters the body and induces an immune response. Similar to a lock and key, antigens specifically bind to their respective antibodies via the epitopes that ar [..]
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B cell precursors
- B lineage cells that are produced in the bone marrow before maturing into B cells.
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binding affinity
- the strength of the interaction between a single antigen binding site on an antibody and a single epitope on an antigen.
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Broadly neutralizing antibodies
- antibodies that are capable of neutralizing a wide range of HIV-1 strains; however, they are rarely made during infection and are difficult to detect. The main focus of the Duke CHAVI-ID is to desi [..]
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CH505
- the Env that was obtained from patient CH505 who developed neutralization breadth during follow-up from acute HIV-1 infection. This person was the first CHAVI 17 participant who was studied for ant [..]
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CHAVI 17
- 17 participants with acute HIV-1 infection in the CHAVI 001 study who developed neutralization breadth during follow-up.
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Clonal lineage
- a lineage of evolved mutated antibodies that are derived from a common unmutated ancestor antibody.
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