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Definitions (31)
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AADC
Aromatic L-amino acid decarboxylase, AADC, is the enzyme responsible for converting L-DOPA into Dopamine. Within the brain, AADC is most abundant in a region called the substantia nigra, which contain [..]
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AAV
Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species without causing disease. AAV can infect both dividing and non-dividing cells and only rarely incorpora [..]
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BDNF
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are produced and trafficked in the adult brain. BDNF becomes deficient in [..]
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Cannula
A cannula (plural: cannulae) is a flexible tube which can be inserted into the body either to withdraw fluid or to deliver medication. The most widely known cannulae are used for intravenous delivery [..]
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CDNA
Complementary DNA (cDNA) is DNA that encodes a protein and is synthesized from a mature messenger RNA template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA can be engineered into [..]
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dopamine
Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. It is important for the control of motor function and neuron-to-neuron [..]
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Dyskinesia
Dystonia (or dyskinesia) is a neurological movement disorder in which sustained muscle contractions cause twisting and repetitive movements or abnormal postures. (Dyskinesia
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FMT-PET
FMT stands for fluoro-metatyrosine, a synthetic substrate for AADC. The enzyme converts FMT mainly to 6-fluoro-hydroxyphenylacetic acid, and this metabolite remains trapped within the tissue where AAD [..]
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